February 10, 2018

Download e-book for kindle: Advances in protein chemistry. / Volume 9 by M L Anson; Kenneth Bailey; John T Edsall

By M L Anson; Kenneth Bailey; John T Edsall

ISBN-10: 008058182X

ISBN-13: 9780080581828

ISBN-10: 012034209X

ISBN-13: 9780120342099

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Extra resources for Advances in protein chemistry. / Volume 9

Example text

It has been shown (Arnstein and Neuberger, 1953a) that the p-carbon atom of serine is quantitatively the most important source of methyl groups, and it is likely that it is also a major precursor of positions 2 and 8 of purines. On this assumption, the synthesis of one purine molecule requires two molecules of serine but only one of glycine, and purine synthesis, as well as the biosynthesis of methyl groups from serine, leads to a net formation of glycine, which is required for the synthesis of other compounds such as creatine and porphyrins.

Although this may indicate a decrease in the synthetic capacity with age, it is more likely to be due to the smaller proportion of metabolically active tissue in older animals. From the data given by Donaldson (1924) it may be calculated that the weight of liver per 100 g. 7 g. , and the amount of glycine synthesized per g. 39 millimole per day, respectively. The rate of glycine formation in adult mice has also been calculated (Barton, 1951), though by a different method which involved the measurement of the conversion of intravenously injected glycine into respiratory carbon dioxide.

And the amount of glycine synthesized per g. 39 millimole per day, respectively. The rate of glycine formation in adult mice has also been calculated (Barton, 1951), though by a different method which involved the measurement of the conversion of intravenously injected glycine into respiratory carbon dioxide. The value of 1 millimole per day per 100 g. body weight thus obtained is of the same order of magnitude as that found for rats, although there appears to be a small but definite species difference.

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Advances in protein chemistry. / Volume 9 by M L Anson; Kenneth Bailey; John T Edsall


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