By Association of Nurses in AIDS Care (ANAC)
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Extra info for ANAC's Core Curriculum for HIV AIDS in Nursing, Third Edition
3. Normal immunology (Medzhitov, 2007) a. Cells of the immune system i) Types of leukocytes (white blood cells) (1) Neutrophils: Major phagocytic cells in the blood. They represent approximately 60% of circulating leukocytes. Production is regulated by inflammatory cytokines: GCSF and GMCSF. (2) Eosinophils: Participate in allergic reactions. They represent 5% of circulating leukocytes. (3) Basophils: Involved in early inflammatory reactions. They represent approximately 1% of circulating leukocytes.
1) The South is the only region where the AIDS rate continues to rise. (2) The largest proportion (Ͼ 80%) of reported cases is in larger urban areas. (3) Women account for Ͼ 25% new cases each year. (a) Greater than 75% of new cases in women occur among African Americans. (4) The disproportionately high rate of HIV infection and AIDS among black and Hispanic men, women, and children has been a constant pattern throughout the epidemic—and the disparity is growing. (a) This overrepresentation initially reflected the higher prevalence in drug users, their sexual partners, and offspring, but it is now seen in nearly every transmission category.
2) Budding (a) A virion core comprised of HIV RNA, structural proteins, and enzymes migrates to the plasma membrane of the host T cell. (b) The virion core buds from the host T cell’s membrane, pushes itself into the extracellular space, taking with it a part of the host’s cell membrane, which it uses for its own envelope. (c) During budding, gpl20 and gp4l are incorporated into the outer lipid membrane of the virion along with some of the host T cell’s protein, which facilitates virion infection of other host T cells.
ANAC's Core Curriculum for HIV AIDS in Nursing, Third Edition by Association of Nurses in AIDS Care (ANAC)
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